Journal of Pharmaceutical Investigation
- Volume 22 Issue 1
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- Pages.55-62
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Studies on the Bioavailability of Berberine Preparations
베르베린 제제의 생체 이용율에 관한 연구
- Yang, Jae-Heon (College of Pharmacy, Jeon Ju Woosuk University) ;
- Kim, Young-Il (College of Pharmacy, Jeon Ju Woosuk University)
- Published : 1992.03.20
Abstract
In order to measure the bioavailability of Coptidis Rhizoma preparations, berberine was extracted by the mixture (1:1 v/v) of methanol and water from Coptidis Rhizoma and formulated into pills with some excipients. Disintegration time, dissolution rate, intestinal absorption rate, antibacterial effect, and serum concentration were measured. All pills were disintegrated about 60 minutes in gastric and intestinal juices and disintegration time did not change upon storage at