생약학회지 (Korean Journal of Pharmacognosy)
- 제23권4호
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- Pages.268-275
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- 1992
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
$CCl_4$ 로 독성유발시킨 초대배양 간세포를 이용하여 간세포 보호효과를 나타내는 생약류의 검색
Screening of Medicinal Plants Having Hepatoprotective Activity Effects with Primary Cultured Hepatocytes Intoxicated Using Carbon tetrachloride Cytotoxicity
- Lee, June-Woo (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.,) ;
- Choi, Joon-Han (Natural Products Lab., Il Yang Pharmaceutical Co., Ltd.,) ;
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Kang, Sang-Mo
(Department of Microbial Engineering, College of Engineering, KonKuk University)
- 발행 : 1992.12.30
초록
We studied to screen medicinal plants having hepatoprotective activity with the primary cultured rat hepatocytes intoxicated with carbon tetrachloride cytotoxicity. The lowest concentration and treatment time of carbon tetrachloride giving the greatest intoxication to the primary cultured hepatocytes were observed in 10mM and 60 minutes, respectively. GTP and GOT activity of culture broth of the primary cultured rat hepatocytes intoxicated by
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