생약학회지 (Korean Journal of Pharmacognosy)
- 제23권2호
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- Pages.81-88
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- 1992
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
간의 Bromobenzene 대사계에 미치는 Scoparone의 효과(I)
The Effect of Scoparone on the Hepatic Bromobenzene Metabolizing Enzyme System in Rats
- Kim, Eun-Ju (College of Pharmacy, Kyungsung University) ;
- Lee, Chung-Kyu (College of Pharmacy, Kyungsung University) ;
- Choi, Jong-Won (College of Pharmacy, Kyungsung University)
- 발행 : 1992.06.30
초록
The effects of scoparone, one of coumarin derivative on the hepatic bromobenzene metabolizing enzyme system was estimated in rats. Scoparone pretreatment revealed dose-dependently the recovery of decrease in epoxide hydrolase activity due to the bromobenzene(310 mg/kg, i.p.) treatment. And also scoparone and scopoletin (each 5mg/kg, p.o.) pretreatments showed two times increase in the
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