Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Studies on Combined Usage of Combined Preparation of Crude Drugs and Anti-neoplastic Drugs(II) -Alleviative effect of cis-Platin and Mitomycin C through Combined Usage of Gamidaebo-Tang-

생약복합제제(生藥複合製劑)와 항암제(抗癌劑)의 병용투여(倂用投與)에 관한 연구(硏究) (제2보)(第2報) -cis-Platin 및 Mitomycin C와 가미대보탕(加味大補湯)의 병용투여(倂用投與)에 의한 부작용(副作用) 경감(輕減) 효과-

  • Hong, Nam-Doo (East-West Medical Research Institute, Kyung Hee University) ;
  • Kim, Jong-Woo (East-West Medical Research Institute, Kyung Hee University) ;
  • Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University) ;
  • Kim, Jin-Sik (College of Pharmacy, Kyung Hee University)
  • 홍남두 (경희대학교 동서의학연구소) ;
  • 김종우 (경희대학교 동서의학연구소) ;
  • 김남재 (경희대학교 동서의학연구소) ;
  • 김진식 (경희대학교 약학대학)
  • Published : 1992.06.30
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Abstract

The water extract of Gamidaebo-Tang depressed the lethal toxicity of cis-platin$(45{\mu}M/kg,\;s.c.)$, and mitomycin C (6mg/kg, s.c.). Significant depression of renal toxicity(indicated by an increased blood urea nitrogen value and creatinine value) of cis-platin $(35{\mu}M/kg)\;s.c.)$, was observed in mice treated with Gamidaebo-Tang. In rats treated with mitomycin C and Gamidaebo-Tang, the increased LDH activity and reduced total protein and albumin contents by mitomycin C were significantly depressed. The number of WBC was significantly increased in rats treated with mitomycin C but in the rats treated with mitomycin C and Gamidaebo-Tang, the number of WBC was increased and the hematocrit value and the number of RBC and Hgb were significantly increased in the dose-dependent manner. Therefore, bone marrow toxicity of mitomycin C in the rats treated with Gamidaebo-Tang was depressed. In the end, alleviative effects of the side actions of cis-platin and mitomycin C were acknowledged by combined usage of Gamidaebo-Tang and these anti-neoplastic drugs.

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