The Korean Journal of Pharmacology (대한약리학회지)
- Volume 28 Issue 2
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- Pages.115-128
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- 1992
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- 0377-9459(pISSN)
Effects of CDP-Choline, Aminoguanidine and Difluoromethylornithine on the ECS-induced Impairment of Active Conditioned Response Retention
백서의 조건회피반응-유지에 대한 경련성 전기충격의 저해작용에 미치는 CDP-Choline, Aminoguanidine, 및 Difluoromethylornithine의 영향에 관한 연구 : 뇌내 Acetylcholine과 Polyamine 함량-변동에 연관하여
- Kim, Hyung-Gun (Department of Pharmacology, Korea University College of Medicine) ;
- Kim, Chang-Hyun (Department of Pharmacology, Korea University College of Medicine) ;
- Choi, Sang-Hyun (Department of Pharmacology, Korea University College of Medicine) ;
- Ihm, Suk-Young (Department of Pharmacology, Korea University College of Medicine) ;
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Lee, Min-Soo
(Department of Psychiatry, Korea University College of Medicine) ;
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Chun, Boe-Gwun
(Department of Pharmacology, Korea University College of Medicine)
- 김형건 (고려대학교 의과대학 약리학교실) ;
- 김창현 (고려대학교 의과대학 약리학교실) ;
- 최상현 (고려대학교 의과대학 약리학교실) ;
- 임숙영 (고려대학교 의과대학 약리학교실) ;
-
이민수
(고려대학교 의과대학 정신과학교실) ;
-
전보권
(고려대학교 의과대학 약리학교실)
- Published : 1992.12.30
Abstract
The training of male wistar rats for active conditioned response (ACR) was performed by one daily training session of 30 consecutive trials for 10 successive days using a two-way shuttle box, and the rats that showed 10 or more ACRs on the last day were treated for further 10 days with electroconvulsive shock (ECS : 50 mA, 0.5 msec; 100 Hz; 1.5 sec) and the following compounds. On the 20th day, all the rats were tested for the ACR rention. The ECS regimens were one ECS per day for 10 days with one day interval
Two-way shuttle box에서 active conditioned response (ACR)을 10일간 매일 30회 부하하여 10회 이상 반응한 웅성 Wistar 백서를 이용하여, 경련성 전기충격 (ECS: 50 mA, 100 Hz, 1.5 sec)에 의한 ACR-유지의 변동에 미치는 CDP-choline (250 mg/kg/day/CC), aminoguanidine (100 mg/kg/day: AG),
Keywords
- Active conditioned response;
- Electroconvulsive shock;
- Acetylcholine;
- CDP-choline;
- Polyamine;
- Aminoguanidine