약학회지 (YAKHAK HOEJI)
- 제36권6호
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- Pages.604-610
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Acyclonucleoside류의 합성(7) -6-아자유리딘의 2',3'-seco유도체의 합성-
Synthesis of Acyclonucleosides -Synthesis of 2',3'-seco derivatives of 6-Azauridine-
- Shin, Dae-Hong (College of Pharmacy, Seoul National University) ;
- Yang, Jae-Wook (College of Pharmacy, Seoul National University) ;
- Kim, Joong-Hyup (Korea Institute of Science and Technology) ;
- Chung, Won-Keun (College of Pharmacy, Seoul National University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University)
- 발행 : 1992.12.29
초록
Synthesis of 6-aza-2´-azido-2´,3´-secouridine, 6-aza-2´,3´-diazido-2´, 3´-secouridine, and 6-aza-5´-azido-2´,3´-secouridine as potential antiviral agents is described. These acyclic nucleosides were synthesized from uridine by the method of ring opening reaction of sugar moiety. And these compounds were tested against HSV-1 and HSV-2, but the in vitro test results of these compounds were negative.