YAKHAK HOEJI (약학회지)
- Volume 36 Issue 6
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- Pages.598-603
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Effects of Various Formulations on Bioavailability of Acetaminophen Soft Gelatin Capsules in Rabbits
토끼에서 아세트아미노펜 연집캅셀제의 생체이용율에 미치는 제제처방들의 영향
- Park, Gee-Bae (College of Pharmacy, Chung-Ang University) ;
- Lee, Yong-Suk (College of Pharmacy, Chung-Ang University) ;
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Choi, Myung-Ho
(College of Pharmacy, Chung-Ang University) ;
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Lee, Do-Ik
(College of Pharmacy, Chung-Ang University) ;
- Lee, Kwang-Pyo (College of Pharmacy, Chung-Ang University)
- Published : 1992.12.29
Abstract
The purpose of this study was to assess the effect of three formulations; product A (polyethylene glycol was used as a main dispersing agent), product B (wax mixture was used as a main dispersing agent) and product C(silicon dioxide was used as a main dispersing agent) on bioavailability of acetaminophen soft gelatin capsules(softgels) and to develop an effective acetaminophen softgel which exhibits an excellent bioavailability. Acetaminophen softgels of various formulations were prepared as 4 minim round type by rotary die method. Four softgels of the three formulation (A, B, C), each of which contained 50 mg acetaminophen, were administered orally to 12 normal healthy rabbits using a three-way cross over design. Plasma acetaminophen concentrations were measured by HPLC. The results obtained in this study were as follows: 1. The Tmax rank order of acetaminophen softgel was C