YAKHAK HOEJI (약학회지)
- Volume 36 Issue 5
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- Pages.460-468
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Age-associated Alteration in the Hapatic Superoxide Generation and Antioxidant Activities in the Senescence-accelerated Mice
노화촉진 생쥐에서 노화에 따른 활성산소 생성 및 항산화능의 변화
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Chung, Hae-Young
(College of Pharmacy, Pusan National University) ;
- Kim, Yun-Kyung (College of Pharmacy, Pusan National University)
- Published : 1992.10.29
Abstract
Several bichemical parameters related to free radicals were estimated in senile-prone (P) and resistant(R) strains of male senescence-accelerated mice(SAM) at 2, 5 and 11 months of age. The superoxide generation was increased with age in SAM-R/1 and SAM-P/2. Compared to SAM-R/1, more generation of superoxide was significantly noted in the SAM-P/2 liver. The activities of Cu/Zn-superoxide dismutase and catalase were decreased during aging and these activities in SAM-P/2 were significantly lower than in SAM-R/l liver. The activities of glutathione S-transferase were varied with aging, whereas SAM-P/2 showed lower levels compared to SAM-R/l. The gradual decreases of glutathione, protein bound-SH and nonprotein bound-SH contents were noted with increasing age. SAM-P/2 liver contained lesser amounts of glutathione and nonprotein bound-SH compared to SAM-R. In conclusion, superoxide generation was increased whereas the antioxidant enzyme activities were decreased during aging in SAM-R/1. In addition, SAM-P/2 strain showed more superoxide generation and less antioxidant enzyme activities than SAM-R/1 in the liver, thus we assume that these factors might accelerate the senescence of SAM-P/2 strain.
Keywords
- Superoxide;
- Cu/Zn-superoxide dismutase;
- glutathione S-transferase;
- catalase;
- glutathione;
- nonprotein bound-SH;
- protein bound-SH