YAKHAK HOEJI (약학회지)
- Volume 36 Issue 5
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- Pages.433-439
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of N-(disubstituted styryl) Carboxamides
N-(2치환스티릴) 카르복사미드류의 합성
- Kim, Soon-Ok (Department of Chemistry, Sungshin Women's University) ;
- Hong, Sa-Mi (Department of Chemistry, Sungshin Women's University) ;
- Lee, Seon-Hwa (Department of Chemistry, Sungshin Women's University)
- Published : 1992.10.29
Abstract
For the synthesis of tuberin derivatives, N-(disubstituted styryl) carboxamides, the series of cinnamic acids were transformed through chlorides, azides to isocyanates. And then isocyanates were reduced separately by Dibal and Grignard reagent. As a result of antimicrobial susceptibility test, N-(3,4-dichlorostyryl) formamide and N-(3,4-dichlorostyrl) acetamide showed comparatively large activity against some bacteria that is, MIC was respectively 50 ppm,
Keywords
- Tuberin;
- N-(dichloro styryl) formamide;
- N-(dichloro styryl) acetamide;
- N-(dimethoxy styryl) formamide;
- N-(dimethoxy styryl) acetamide;
- Curtius rearrangement;
- antimicrobial susceptibility test