YAKHAK HOEJI (약학회지)
- Volume 36 Issue 4
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- Pages.341-344
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of 5-(p-Toluoyl)-1-Methylpyrrole-2-Acetic Acid [Tolmetin]
5-(p-톨루오일)-1-메틸피롤-2-아세트산의 합성
- Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
- Ma, Jung-Joo (Department of Chemistry, Dongeui University)
- Published : 1992.08.29
Abstract
A facile method for tolmetin, which is a potent antiinflammatory agent, is described. Friedel-Crafts reaction of 1-methylpyrrole with ethyl
Keywords
- Tolmetin;
- a potent antiinflammatory agent;
- Friedel-Crafts reaction;
- 1-methylpyrrole;
- ethyl ${\alpha}-chloro-{\alpha}-(methylthio)acetate$;
- reductive desulfurization;
- Friedel-Crafts acylation;
- p-toluoyl chloride;
- hydrolysls