약학회지 (YAKHAK HOEJI)
- 제36권2호
- /
- Pages.173-179
- /
- 1992
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
생강추출물의 항위염 . 항궤양 작용
Antigastritic and Antiulcerative Action of the Extract of Zingiberis Rhizoma
- 양원경 (덕성여자대학교 약학대학) ;
-
정춘식
(덕성여자대학교 약학대학) ;
-
정기화
(덕성여자대학교 약학대학) ;
- 김재완 (덕성여자대학교 약학대학) ;
-
이은방
(서울대학교 천연물과학연구소)
- Yang, Won-Kyung (College of Pharmacy, Duksung Women's University) ;
-
Jung, Chun-Sik
(College of Pharmacy, Duksung Women's University) ;
-
Jung, Ki-Wha
(College of Pharmacy, Duksung Women's University) ;
- Kim, Jae-Wan (College of Pharmacy, Duksung Women's University) ;
-
Lee, Eun-Bang
(Natural Product Research Institute, Seoul National University)
- 발행 : 1992.04.29
초록
The rhizoma of Zingiber officinale has been used as antiemetic, expectorants, stomachache relieving drugs and digestive accelerators. From the observation of antigastritic action of the methanol extract of the rhizoma, it was fractionated with hexane, chloroform, ethyl acetate and butanol, followed by bioassay on antigastritic and antiulcerative activity. The hexane and the chloroform fraction reduced significantly HCl ethanol induced gastric lesion at the dose of 370 and 210 mg/kg, p.o., respectively. On the gastric ulceration and gastric secretion in pylorus-ligated rats, the hexane fraction decreased the volume of gastric secretion and acid output, and also increased pH at the dose of 370 mg/kg, i.d.. It showed considerable curative ratio of acetic acid induced ulcer without inhibition of indomethacin induced gastric lesion. The methanol extract showed low acute toxicity with minimum lethal dose of more than 3000 mg/kg, p.o. in mice. In conclusion, Zingiberis rhizoma exhibited antigastric and antiulcerative activity which might be attributable to inhibition of gastric secretion. It is revealed that the active component may be present in the hexane fraction.
키워드