약학회지 (YAKHAK HOEJI)
- 제36권2호
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- Pages.159-166
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
N-스테아릴락토비온아미드의 합성과 이를 이용한 리포좀의 제조
Synthesis of N-Stearyl lactobionamide(N-SLBA) and Preparation of Neo-galactosylated Liposome
- 김종국 (서울대학교 약학대학 물리약학연구실) ;
- 민미홍 (서울대학교 약학대학 물리약학연구실) ;
- 민경희 (서울대학교 약학대학 물리약학연구실) ;
- 나운용 (서울대학교 약학대학 물리약학연구실) ;
- 이봉진 (서울대학교 약학대학 물리약학연구실) ;
- 김양배 (서울대학교 약학대학 물리약학연구실)
- Kim, Chong-Kook (College of Pharmacy, Seoul National University) ;
- Min, Mi-Hong (College of Pharmacy, Seoul National University) ;
- Min, Kyoung-Hee (College of Pharmacy, Seoul National University) ;
- Lah, Woon-Ryong (College of Pharmacy, Seoul National University) ;
- Lee, Bong-Jin (College of Pharmacy, Seoul National University) ;
- Kim, Yang-Bae (College of Pharmacy, Seoul National University)
- 발행 : 1992.04.29
초록
A neoglycolipid, N-stearyl lactobionamide(N-SLBA) was synthesized and the incorporation of the neoglycolipid into liposomes was achieved in order to prepare neo-galactosylated liposome as potential drug carrier for active targeting to galactose receptor existing cell and tissue. N-SLBA was synthesized by the covalent linkage between carboxyl group of lactobionic acid and amino group of stearylamine(SA). The yield of N-SLBA was about 52.3%. It was identified with