약학회지 (YAKHAK HOEJI)
- 제36권2호
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- Pages.110-114
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
1,4-나프토퀴논 유도체의 항균 및 항진균 작용
Antibacterial and Antifungal Activities of 1,4-Naphthoquinone Derivatives
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University) ;
- Ryu, Jae-Chun (Doping Control Center, KIST) ;
- Chung, Sae-Young (College of Pharmacy, Kyung Hee University) ;
- Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
- 발행 : 1992.04.29
초록
In order to evaluate the antimicrobial effect of 2, 3-substituted-1, 4-naphthoquinone derivatives, we newly synthesized several 2-chloro, 2-bromo and 2-hydroxy-1, 4-naphthoquinones and subjected to antibacterial and antifungal activities, in vitro, against Escherichia coli NIHJ, Staphylococcus aureus ATCC6538p, Candida albicans 10231, Aspergillus niger 1231 and Tricophyton mentagrophytes 6085. Among these derivatives 3, 9, 18 and 23 showed the potent antibacterial activities. 18, 23 and 28 have the antifungal activities. However, these compounds have no significant hemolytic activity at concentrations higher than that required for showing the antibacterial and antifungal activities.
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