The Korean Journal of Physiology
- Volume 26 Issue 2
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- Pages.137-141
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- 1992
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- 0300-4015(pISSN)
Mode of Inhibitory Action of Amitriptyline on Carbachol-Induced Contraction of Isolated Rabbit Detrusor Muscle
- Gill, Won-Sik (Department of Physiology, Chonnam University Medical School) ;
- Shin, Beong-Ho (Department of Physiology, Chonnam University Medical School) ;
- Kim, Won-Jae (Department of Physiology, Chonnam University Medical School) ;
- Jeong, Han-Seong (Department of Physiology, Chonnam University Medical School)
- Published : 1992.12.01
Abstract
The present study was aimed at elucidating the mode of inhibitory action of tricyclic antidepressants on the smooth muscle. Effects of amitriptyline on the isolated detrusor muscle strips of the urinary bladder of the rabbit were examined. The spontaneous rhythmic movement of the muscle preparation was frequently observed, which was decreased or abolished by addition of amitriptyline