The Journal of Natural Sciences (자연과학논문집)

  • Volume 4
  • /
  • Pages.23-28
  • /
  • 1991
  • /
  • 1225-6196(pISSN)
Research Institute of Natural Sciences (배재대학교 자연과학연구소)
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Synthesis of Multisubstrate analog Inhibitor of Thymidylate synthase

Thymidylate Synthesis의 Multisubstrate analog Inhibitor의 합성

  • 곽인영 (배재대학교 이공대학 유전공학과) ;
  • 유응걸 (한국화학연구소 유기1부 5실)
  • Published : 1991.02.01
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Abstract

The pyrimidy1 derivative of 2'-deoxythmidine 5'-monophosphate, 3 has been synthesized for the development of anticanncer agents. The compound 3 derived from prototype inhibitor 2 by modifying the p-aminobenzoy1 glutamic acid portion has been designed to facilitate the membrane penetration. Variable temperature $^1H$ NMR spectrum for the protected nucleotide has indicated the existence of two conformers which are stable on the NMR time scale at ambient temperature.

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