The Journal of Natural Sciences (자연과학논문집)
- Volume 4
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- Pages.23-28
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- 1991
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- 1225-6196(pISSN)
Synthesis of Multisubstrate analog Inhibitor of Thymidylate synthase
Thymidylate Synthesis의 Multisubstrate analog Inhibitor의 합성
- Published : 1991.02.01
Abstract
The pyrimidy1 derivative of 2'-deoxythmidine 5'-monophosphate, 3 has been synthesized for the development of anticanncer agents. The compound 3 derived from prototype inhibitor 2 by modifying the p-aminobenzoy1 glutamic acid portion has been designed to facilitate the membrane penetration. Variable temperature
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