Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Electron Microscopic Ultrastructural Changes of Leiomyoma after Treatment with D-Trp6-Luteinizing Hormone Releasing Hormone

자궁근종시 LHRH agonist (D-Trp6-LHRH) 치료에 따른 근종세포내 미세구조의 변화

  • Park, K.H. (Department of Obstetrics and Gynecology, Yonsei University, College of Medicine) ;
  • Shin, M.C. (Department of Obstetrics and Gynecology, Yonsei University, College of Medicine) ;
  • Lee, B.Y. (Department of Obstetrics and Gynecology, Yonsei University, College of Medicine) ;
  • Lee, B.S. (Department of Obstetrics and Gynecology, Yonsei University, College of Medicine) ;
  • Song, C.H. (Department of Obstetrics and Gynecology, Yonsei University, College of Medicine)
  • 박기현 (연세대학교 의과대학 산부인과학교실) ;
  • 신명철 (연세대학교 의과대학 산부인과학교실) ;
  • 이보연 (연세대학교 의과대학 산부인과학교실) ;
  • 이병석 (연세대학교 의과대학 산부인과학교실) ;
  • 송찬호 (연세대학교 의과대학 산부인과학교실)
  • Published : 1991.12.31
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Abstract

Long-term administration of luteinizing hormone-releasing hormone(LHRH) agonists, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used D-Trp6-LHRH, a long acting LHRH agonist, for the treatment of eleven patients with uterine leiomyomas, thereafter myomectomy was performed in seven cases and observed the ultrastructural changes of leiomyoma with an electron microscope. The use of LHRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal. Electron microscopic findings of myoma cells after the use of LHRH agonist included the following: loss of cristae and swelling nuclear chromatin, perinuclear vacuolation in cytoplasm. Bone mineral density was slightly decreased, however, the difference was not statistically significant.

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