The monomer, 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU) was synthesized from trans-${\beta}$-carbomethoxyacryl chloride and 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine. A copolymer of CMAFU with methyl methacrylate (MMA)[poly(CMAFU-co-MMA)] was also prepared with 2, 2'-azobisisobutyronitrile in cyclohexanone at $60^{\circ}C$. Physiological genetic effects of 5-fluorouracil(5-FU), CMAFU and poly(CMAFU-co-MMA) on Drosophila melanogaster were investigated by the adult feeding method of Lewis and Bacher. It was found that a physiological genetic effect on the Drosophila melanogaster was considerably weaker for CMAFU and its copolymer than 5-FU.
1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU)을 trans-${\beta}$-carbomethoxyacryl chlocide와 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine으로부터 합성하고, CMAFU와 메틸메타크릴레이트를 cyclohexanone을 용매로 사용하여 $60^{\circ}C$에서 라디칼공중합을 하였다. 5-FU, CMAFU 및 poly(CMAFU-Co-MMA)들이 노랑초파리에 미치는 생리유전학적 영향을 Lewis와 Bacher 방법에 의하여 조사한 결과, CMAFU와 그 중합체가 5-FU 보다 생리유전학적 영향이 약함을 알 수 있었다.
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Supported by : Korea Science and Engineering Foundation