Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Physiological Genetic Effects of Monomer and Polymer Containing 5-Fluorouracil on Drosophila Melanogaster

5-플루오로우라실을 포함하는 단량체와 중합체의 노랑초파리에 대한 생리유전학적 영향

  • Lee, Neung-Ju (Department of Premedical Sciences, Kosin Medical College) ;
  • Kim, Ik-Sung (Department of Polymer Science and Engineering, Pusan National University) ;
  • Choi, Won-Moon (Department of Polymer Science and Engineering, Pusan National University) ;
  • Ha, Chang-Sik (Department of Polymer Science and Engineering, Pusan National University) ;
  • Cho, Won-Jei (Department of Biology, Pusan National University)
  • 이능주 (고신대학 의예과) ;
  • 김익성 (부산대학교 공과대학 고분자공학과) ;
  • 최원문 (부산대학교 공과대학 고분자공학과) ;
  • 하창식 (부산대학교 공과대학 고분자공학과) ;
  • 조원제
  • Received : 1991.02.25
  • Published : 1991.03.25
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Abstract

The monomer, 1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU) was synthesized from trans-${\beta}$-carbomethoxyacryl chloride and 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine. A copolymer of CMAFU with methyl methacrylate (MMA)[poly(CMAFU-co-MMA)] was also prepared with 2, 2'-azobisisobutyronitrile in cyclohexanone at $60^{\circ}C$. Physiological genetic effects of 5-fluorouracil(5-FU), CMAFU and poly(CMAFU-co-MMA) on Drosophila melanogaster were investigated by the adult feeding method of Lewis and Bacher. It was found that a physiological genetic effect on the Drosophila melanogaster was considerably weaker for CMAFU and its copolymer than 5-FU.

1-(2-carbomethoxyacryloyl)-5-fluorouracil(CMAFU)을 trans-${\beta}$-carbomethoxyacryl chlocide와 2, 4-bis(trimethylsilyloxy)-5-fluoropyrimidine으로부터 합성하고, CMAFU와 메틸메타크릴레이트를 cyclohexanone을 용매로 사용하여 $60^{\circ}C$에서 라디칼공중합을 하였다. 5-FU, CMAFU 및 poly(CMAFU-Co-MMA)들이 노랑초파리에 미치는 생리유전학적 영향을 Lewis와 Bacher 방법에 의하여 조사한 결과, CMAFU와 그 중합체가 5-FU 보다 생리유전학적 영향이 약함을 알 수 있었다.

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Acknowledgement

Supported by : Korea Science and Engineering Foundation