Maxillofacial Plastic and Reconstructive Surgery
- 제13권3호
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- Pages.265-277
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- 1991
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- 2288-8101(pISSN)
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- 2288-8586(eISSN)
백서 복근에 매식된 동결 건조 및 방사선 멸균처리된 동종골의 조직 반응에 관한 실험적 연구
AN EXPERIMENTAL STUDY ON TISSUE RESPONSE FOLLOWING IMPLANTATION OF THE FREEZE - DRIED AND RADIATION - STERILIZED ALLOGENEIC BONE IN RECTUS ABDOMINICUS MUSCLE
- 이창우 (원광대학교 치과대학 구강 악안면 외과학 교실) ;
- 임창준 (원광대학교 치과대학 구강 악안면 외과학 교실) ;
- 이동근 (원광대학교 치과대학 구강 악안면 외과학 교실) ;
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김수남
(원광대학교 치과대학 구강 악안면 외과학 교실)
- Lee, Chang-Woo (Department of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University) ;
- Yim, Chang-Joon (Department of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University) ;
- Lee, Dong-Kuen (Department of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University) ;
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Kim, Soo-Nam
(Department of Oral & Maxillofacial Surgery, College of Dentistry, Wonkwang University)
- 발행 : 1991.12.31
초록
In this study, the healing changes of the implanted bone and its surrounding tissues were examined on the histopathologic basis following implantation of the freeze - dried and radiation - sterilized allogeneic bone in Rectus abdominicus of the rat. This study was performed to see the tissue recations after implantation of the freeze - dried and radiation - sterilized allogeneic bone and whether osteogenesis or osteo - induction or osteo - conduction is happened. And the results were as follows : 1. The shape of the implanted allogeneic bone of the 1, 2 - week group specimen was similar to that of normal bone in light - microscopic finding and the atrophy of cellular organells was found in trans - mission electron - microscopic finding. 2. The implanted allogeneic bone was surrounded with the dense fibroconnective tissues, and infiltration of the chronic inflammatory cells gradually became increased. 3. Hyaline degeneration was observed in the surrounding tissue at the 3, 4, 6 - week group specimen. 4. Light - microscopically the resorption of implanted bone became prominent after 4 - week group and the necrosis of allogeneic bone implant became severe with loss of cell components in lacuna. 5. Electron - microscopically, the osteoclast - like cells ere fond after, 2 - week group. It is summarized that the osteo - conduction potential of the bone is remained just after implanting the freeze - dried and radiation - sterilized allogeneic bone on Rectus abdominicus of the rat, but gradually it disappeared with the gradual increse of chronic inflammatory reaction and osteoclastic activity. So it is suggested that the antigenicity of the freeze - dried and radiation - sterilized bone is remained and it has little osteo - conductive activity when it is implanted in the muscle.
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