Korean Journal of Veterinary Research (대한수의학회지)
- Volume 31 Issue 3
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- Pages.265-270
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- 1991
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Effect of dietary vitamin E on the lipid peroxidation by dietary iron injected to male rats
Vitamin E가 철분 투여로 인한 rat의 지질 과산화에 미치는 영향
- Huh, Rhin-sou (College of Veterinary Medicine, Kyungpook National University) ;
- Kim, Young-hong (College of Veterinary Medicine, Kyungpook National University) ;
- Do, Jae-cheul (College of Veterinary Medicine, Kyungpook National University) ;
- Choi, Yeon-shik (College of Veterinary Medicine, Kyungpook National University) ;
- Cheong, Cheong-won (College of Veterinary Medicine, Kyungpook National University)
- Received : 1991.05.02
- Published : 1991.07.31
Abstract
This study was designed to investigate the effect of dietary vitamin E on the lipid peroxidation by dietary iron-injected to male rats. Sprague-Dawely strain male rats were divided into three experimental groups, namely control, iron injected and iron-vitamin E injected groups. The control group was fed with normal diet; the iron injected group was given normal diet and while injected intraperitoneally 30mg of ferric hydroxide/100g of body weight 20 times every 3 days. The iron-vitamin E injected group was intraperitoneally administered 30mg of ferric hydroxide/100g of body weight 20 times every 3 days and vitamin E every day with the dose of 5IU(5mg)/100g body weight. All experimental groups were maintained for 60 days with feeding on the respective ratio. The results obtained from this experiment were summarized as following: 1. The net weight gain was significantly decreased by the iron injection, but much increased by the vitamin E injection. 2. The contents of unsaturated fatty acid in phospholipid in liver, kidney, muscle and serum were decreased by the iron injection, but increased by the vitamin E injection. 3. The increment of malondialdehyde contents was induced by the iron overloading, but significantly decreased by the vitamin E injection. Therefore, it is suggested that dietary iron administration to male rats facilitates the lipid peroxidation in vivo and vitamin E has the inhibiting effect on lipip peroxidation process by iron.
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