Asian-Australasian Journal of Animal Sciences
- 제4권1호
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- Pages.15-19
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- 1991
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- 1011-2367(pISSN)
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- 1976-5517(eISSN)
DOI QR Code
RESTRICTION BY MOTHERWORT (Leonurus sibiricus L) OF LACTATION SUPPRESSED BY PREGNANCY-DEPENDENT MAMMARY TUMORS IN GR/A MICE
- Nagasawa, H. (Experimental Animal Research Laboratory, Meiji University) ;
- Suzuki, M. (Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida) ;
- Inatomi, H. (Laboratory of Natural Product Chemistry, Meiji University) ;
- Hibino, A. (Laboratory of Natural Product Chemistry, Meiji University) ;
- Yamamuro, Y. (Department of Animal Breeding, College of Agriculture and Veterinary Medicine, Nihon University) ;
- Sensui, N. (Department of Animal Breeding, College of Agriculture and Veterinary Medicine, Nihon University)
- 투고 : 1990.04.23
- 심사 : 1990.11.04
- 발행 : 1991.03.01
초록
As a possible step to evaluate in the mammary gland the role of motherwort (Leonurus sibiricus L), a representative medicinal plant used traditionally for the therapy of gynecologic diseases, the effects of the agent on lactation which was suppressed by preganacy-dependent mammary tumors (PDMT) were studied in GR/A mice. Beginning the day of placing with males at 45-50 days of age, female mice were given 60% methanol-extract of the aerial part of motherwort as drinking water at the concentration of 0.5% throughout the experiment. Mice developing PDMT during pregnancy [PDMT(+)] and given motherwort were similar to mice developing no PDMT [PDMT(_)] with or without motherwort treatment and were significantly higher than PDMT(+) mice given tap water in litter growth and mammary RNA/DMA ratio on day 12 of the 2nd lactation. Mammary DNA and RNA contents were also elevated by motherwort in PDMT(+) mice. The results suggest that motherwort can ameliorate lactation suppressed by PDMT through its stimulation of both growth and function of the mammary glands.