Maxillofacial Plastic and Reconstructive Surgery
- Volume 13 Issue 4
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- Pages.391-404
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- 1991
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- 2288-8101(pISSN)
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- 2288-8586(eISSN)
CHEMOSENSITIVITY TEST OF HUMAN OSTEOSARCOMA AND EPIDERMOID CARCINOMAS USING MTT ASSAY
MTT법을 이용한 사람 골육종과 상피암 세포주들에 대한 항암제 감수성 검사
- Park, Sung-Oh (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Chongbuk National University) ;
- Shin, Hyo-Keun (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Chongbuk National University) ;
- Kim, Oh-Whan (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Chongbuk National University)
- Published : 1991.12.31
Abstract
Three anticncer agents which are different in time or dosage dependence as well as in phase specificity, namely mitomycin and adriamycin from natural products, and widely different cancer cell lines_Four epidermoid carcinomas originated from larynx, cervix, skin and gut were used toghether with one osteosarcoma as the target cell of single and combined administration of anticancer drugs. Semiautomated tetrazolium dye assay(MTT) appears to offer an attractive option for chemosensitivity of head and neck cancers since it is a simple, valid and inexpensive method of assessing chemosensitivity for large samples in a short time. The results obtained form this study were as follows. 1. Good correlations were obtained with the results of the MTT test and those of
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