Bulletin of the Korean Chemical Society

  • 제12권2호
  • /
  • Pages.127-130
  • /
  • 1991
  • /
  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Total Synthesis of Fosfazinomycin A

  • Ik Joong Kang (Department of Chemical Engineering, Kyungwon University) ;
  • Suk In Hong (Department of Chemical Engineering, Korea University) ;
  • Yong Joon Kim (Department of Chemical Engineering, Korea University)
  • 발행 : 1991.04.20
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초록

Fosfazinomycin A(1), methyl valylarginylmethylhydrazinohydroxyphosphonohydro xyacetate, has been synthesized. N-Carbobenzyloxyvalylnitroarginine(6) was reacted with methyl methylhydrazinobenzyloxyphosphonobenzyloxyacet ate(10) which has carbon-phosphorus bond, to give a coupled product of methyl N-Carbobenzyloxyvalylnitroarginylmethylhydrazinob enzyloxyphosphonobenzyloxyacetate(11). The deprotection of (11) by hydrogenation yielded Fosfazinomycin A(1).

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