Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 11 Issue 2
- /
- Pages.99-106
- /
- 1991
- /
- 1225-6307(pISSN)
Intracellular Transport of Benzo(a)pyrene by Chemically Modified Low Density Lipoproteins into Hep 2 Cells.
화학적으로 변형된 저밀도 지방단백질에 의한 벤조피렌 화합물의 Hep 2 세포내 이동에 관한 연구
Abstract
Facilitated transport of lipophilic benzo(a)pyrene into human fibroblast cells by low density lipoproteins (LDL) was examined. Amounts of [3H]-labeled B(a)P taken up by the Hep 2 fibroblast was increased 3 folds by the addition of LDL (100ng of protein/105 cells) in the media. However, we have found that the facilitated B(a)P transport into cells were diminished by the addition of LDL of which the apoproteins were modified by copper(II) ion-catalyzed oxidation in 10nM copper sulfate. The results of the present study suggest that lipophilic compounds are taken up via adsorptive endocytosis which is mediated by interactions between apoproteins on LDL.
수용체를 통한 저밀도 지방단백질(LDL)의 세포내 이동과 함께 일어나는 지용성 돌연변이원인 벤조피렌의 세포내 이동에 관하여 조사하였다. [
Keywords