한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)
- 제19권3호
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- Pages.272-280
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- 1991
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- 1598-642X(pISSN)
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- 2234-7305(eISSN)
하이브리도마 세포의 유가식 배양에서 배지첨가속도가 단일클론 항체 생산에 미치는 영향
The Effect of Media Feeding Rate on the Production of Monoclonal Antibody Production in the Fed-batch Culture of Hybridoma
초록
유가식 배양에서 배지첨가속도가 하이브리도마 세포의 증식과 항체생성속도에 미치는 영향을 조사하였다. 항체 비생성속도
The effect of media feeding rate on cell growth and monoclonal antibody production in the fed-batch culture ot hybridoma A4W was studied. In the batch culture, the highest specific antibody production rate was observed at the begining of the culture period but its value tended to decrease rapidly with the culture time. The final antibody concentration and volumetric productivity was 65