Korean Journal of Microbiology (미생물학회지)
- Volume 29 Issue 3
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- Pages.160-166
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- 1991
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- 0440-2413(pISSN)
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- 2383-9902(eISSN)
Regulation of Tubercidin Biosynthesis in Streptomyces tubercidicus by Adenine and Histidine
Streptomyces tubercidicus에서 Adenine과 Histidine에 의한 Tubercidin 생합성 조절
Abstract
The regulatory mechanism of tubercidin biosynthesis in Streptomyces tubercidicus was studied. In a wild type strain, addition of adenine and histidine into the medium decreased the tubercidin production by 60-65% and 40%, respectively. The effects of adenine and histidine were alleviated by the addition of inosine monophosphate and 5-aminoimidazole-4-carboxamide ribotide. The production of tubercidin in S. tubercidicus K115 strain (
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