Korean Journal of Microbiology (미생물학회지)
- Volume 29 Issue 2
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- Pages.111-116
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- 1991
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- 0440-2413(pISSN)
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- 2383-9902(eISSN)
Transformation Pathway of the Progesterone by Rhizopus nigricans
Rhizopus nigricans에 의한 Progesterone 전환 반응의 경로
Abstract
Rhizopus nigricans produces 11.alpha.-hydroxyprogesternoe with a unidentified byproduct, which is hardly separated. Results of chromatography, IR and NMR spectroscopy identified the byproduct to be 11.alpha.-hydroxy-allopregnane-3,20-dione. R. nigricans was found to transform progesternoe into a monoform intermediate, 11.alpha.-hydroxyprogesterone, from which 11.alpha.-hydroxy-allopregnane-3,20-dione and 6.betha., 11.alpha. - dihydroxyprogesterone were formed respectively by 5.alpha.-reduction and 6.betha.-hydroxylation.
Keywords
- Rhizopus nigricans;
- Progesterone;
- 11$\alpha$-hydroxyprogesterone;
- 11$\alpha$-hydroxy-allopregnane-3,20-dione;
- 6$\beta$;
- 11 a-dihydroxyprogesterone