Toxicological Research

  • 제7권2호
  • /
  • Pages.231-238
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  • 1991
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

BIOACTIVATION OF DIBROMOETHANE BY CONJUGATION WITH GLUTAHIONE

  • Kim, Dong-Hyun (Dopin Control Center, Korean Advanced Institute of Science and Technology)
  • 발행 : 1991.12.01
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초록

The pesticide and carcinogen ethylene dibromide(EDB) is metabolized both by cytosolic GSH S-transferase and by microsomal mixed function oxygenase. Cytochrome P-450 IIE1 appears to be major enzyme to metabolize EDB.EDB is activated to a mutagen by enzymatic conjugation with glutathione (GSH). Such activation is an exception to the general mode of detoxification via GSH S-transferase action. The primary DNA adduct (>95) is S-[2-(N7-guanyl)ethyl] GSH and a minor adduct is S-[2-(N7-guanyl)ethyl]cysteine, which is excreted in the urine and may serve as a biomarker of damage.

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참고문헌

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