한국인 집단의 유전학적 연구 16. Compiement Component 6의 유전적 다형

Molecular Genetic Studies of Korean Population. 16. Genetic Polymorphim of the Sixth Complement Component (C6)

한국인 383명의 Compiement Component 6(C6)의 유전적 다형을 등전점 전기영동과 immunoblotting으로 조사하였다. 5가지 allotypes, C6 A, C6 B, C6 B2, C6 Ml, C6 M11이 나타났고, 이들의 대립유전인자 빈도는 C6*A=0.4399, C6*B=0.5144, C6*B2=0.0392로 산출되어 이는 동아시아인과 비슷하였다.

The phenotyping of the sixth complement component (C6) was performed on plasma or serum samples from 383 unrelated Korean, by IEF and immunoblotting using anti-human C6 serum. Three common allotypes, C6 A, C6 B and C6 B2 and two rare allotypes, C6 Ml and C6 Mu were observed. The allele frequencies of C6*A, C6*B and C6*B2 were estimated to be 0.4399, 0.5144, 0.0392, respectively. These frequencies are similar to those of the Eastasian populations.