Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Synthesis of Poly-$N^5$-(3-hydroxypropyl glutamine)/Poly (ethylene glycol)block Copolymer Hydrogel and Its Application to the Artificial Skin

Poly-$N^5$-(3-hydroxypropyl glutamine)/Poly (ethylene glycol)block copolymer hydrogel의 합성과 인공피부에의 응용

  • 조종수 (전남대학교 공과대학 고분자공학과) ;
  • 오상봉 (전남대학교 자연과학대학 화학과, 동국대학교 이과대학 화학과)
  • Published : 1991.03.01
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Abstract

ABA type block copolymers composed of poly($\gamma-benzyl$ L-glutamate) (PBLG) as the A component and poly (ethylene glycol) as the B component were obtained by polymerization of $\gamma-benzyl$ L-gletamate N -carboxyanhydride, initiated by amino groups at both ends of poly(ethylene glycol) . From circular dichroism measurements in ethylene dichloride solution as well as from infrared spectTa measurements in solid state, it was found that the polypep- tide block exists in the a-helical conformation, as in PBLG homopolymer. $Poly-N^5$ (3-hydroxypropyl glutamine) (PHPG)/poly(ethylene glycol)block copolymer hydrogel was obtained by the treatment of PBLG/PBG block copolymer with the mixture of 3-ammine-1-propanol and diamlnooctane. The water content of PHPG/PEG block copolymer hydrogel was about 80wt% when the concentration of crosslinking agent was below 5 mole % per polymer.

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