YAKHAK HOEJI (약학회지)
- Volume 35 Issue 5
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- Pages.389-393
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- 1991
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Facile Synthesis of $(\pm)$ -2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric acid (Indobufen)
$(\pm)$ -2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric acid(인도부펜)의 합성
Abstract
A convenient method for the synthesis of indobufen, which is a potent antiinflammatory agent, was described. Ethyl 2-phenylbutyrate(4) was prepared by Friedel-Crafts reaction of benzene with ethyl
Keywords
- Indobufen;
- a potent antiinflammatory agent;
- ethyl 2-phenylbutyrate;
- Friedel-Crafts reaction;
- ethylation;
- desulfurization;
- ethyl 2-(p-aminophenyl)butyrate;
- nitration;
- reduction;
- condensation reaction;
- hydrolysis