약학회지 (YAKHAK HOEJI)
- 제35권4호
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- Pages.335-340
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- 1991
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
p-Mentha-8-ene-2-one계 향료합성
Synthesis of Odorants p-Mentha-8-ene-2-one Derivatives by the Reaction of Dihydrocarvone with Formaldehyde
초록
The synthetic product of 1-hydroxymethyl-p-mentha-8-ene-2-one was afforded by the reaction between dihydrocarvone and formaldehyde. This reaction involves the aldol condensation. The preferential position of formaldehyde is methyl substituted .alpha.-carbon atom where these enols are regiospecifically formed. The hydroxymethylation of dihydrocarvone was also proved to happen regiospecifically in the position of .alpha.-methyl substituted ketone. When 1-hydroxymethyl-p-mentha-8-ene-2-one reacted with LiAIH