Synthesis and Antifungal Activities of 1-[(2-Phenyl-1,3-benzodioxol-2-yl)methyl]-1H-imidazole Derivatives

1-[(2-Phenyl-1,3-benzodioxol-2-yl)methyl]-1H-imidazole 유도체의 합성 및 항진균작용

The synthesis of 1-[(2-phenyl-1, 3-benzodioxol-2-yl)methyl]-1H-imidazole derivatives is described starting with 2-bromoacetophenones and catechols. 1-[(2-Phenyl-1, 3-benzodioxol-2-yl)methyl]-1H-imidazole (9-$_{12}$) showed potent broad-spectrum activity, not only against Candida species but also Cr. neofortnans, S. cerevisiae and T. mentagrophytes.