YAKHAK HOEJI (약학회지)
- Volume 35 Issue 4
- /
- Pages.283-287
- /
- 1991
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Synthesis of 2,3-Alkyl Substituted N-cyanoaziridines and Their in vitro Cytotoxicity
N-Cyanoaziridine 유도체의 합성 및 항암효과 평가
Abstract
Seven derivatives of 2,3-alkyl substituted N-cyanoaziridine were stereoselectively prepared from alkyl substituted alkenes and cyanamide. NMR spectral property and conformation of N-cyanoaziridine were analysed. Protons(3.34 ppm) at 2,3 position of N-cyanoaziridines are significantly deshielded in case of cyclopentyl fused N-cyanoaziridine. These protons are getting more anisotropically shielded with increasing the fused carbocycle size of N-cyanoaziridine. Therefore chemical shift for these protons are upfield shifted to 2.80 ppm in case of cyclooctyl fused N-cyanoaziridine. Their ED