약학회지 (YAKHAK HOEJI)
- 제35권2호
- /
- Pages.135-141
- /
- 1991
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
효모에서 발현된 유전자 재조합 인간 GM-CSF의 일반 약리작용
General Pharmacology of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor Expressed in Saccharomyces cerevisiae
초록
The general pharmacological tests with rhGM-CSF indicated that it had no influences on rotarod and locomotor activity tests, but shortened hexobarbital-sleeping time at the large dose of 3 mg/kg s.c. in mice. It elicited no hypothermic, analgesic and antiepileptic action. No influences on blood pressure and respiration in rabbits were observed at the dose of 1 mg/kg, i.v. and it did neither affect the receptors of adrenaline, acetylcholine, serotonin, histamine, kinin and oxytocin, nor antagonize the actions of histamine, serotonin and oxytocin at its concentrations of 1