약학회지 (YAKHAK HOEJI)
- 제35권1호
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- Pages.38-44
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- 1991
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
실험적 급성 신장장해 쥐에서 Theophylline의 체내동태(I)
Pharmacokinetics of Theophylline in Experimental Acute Renal Failure Rats(I)
초록
It has been reported that the pharmacokinetic behaviors of drugs which are mostly metabolized in the liver are significantly different in patients with renal failure. Theophylline(TP) is mainly metabolized in the liver (approximately 90%) and renal clearance of the drug is negligible (less than 10%). Therefore, we have investigated the changes in pharmacokinetics of theophylline in normal, G-ARF and U-ARF rats after an intravenous administration. The total body clearance of TP decreased approximately 40% in U-ARF rats. The reduced CL