Journal of Ginseng Research
- 제15권1호
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- Pages.13-20
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- 1991
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
인삼성분이 Cyclophophamide의 면역독성에 미치는 영향
Effects of Ginseng Components on Immunotoxicity of Cyclophosphamide
- Kim, Young-Sook (Korea Ginseng & Tobacco Research Institute) ;
- Kang, Kyu-Sang (Korea Ginseng & Tobacco Research Institute) ;
- Kim, Shin-Il (Korea Ginseng & Tobacco Research Institute)
- 발행 : 1991.04.01
초록
Ginseng components were examined for their ability to modify immunotoxicity of cyclophosphamide. Ginseng polysaccharide fraction (FO, 300 mg/kg) inhibited decreases in the ratio of spleen to body weight, white blood cells (WBC) count and the number of plaque forming cells (PFC) induced by cyclophosphamide (50 mg/kg, i.p.), and increased these variables in normal mice. Ginseng saponin fraction (50 mg/kg) showed to increase hemoglobin content as well as the number of PFC/spleen in normal mice. on the other hand, Panaxytriol (20 mg/kg) Prevented decrease in mc count by cyclophos phamide. Neither saponin fraction nor panaxytriol had any significant effect on the number of PFC and antibody titers in cyclophosphamide-treated mice. These results suggest that ginseng polysaccharine fraction may reduce the immunotoxicity of cyclophosphamide and may be effective in stimulating immune function in normal mice.