한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제1권1호
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- Pages.31-36
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- 1991
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
혈액암 환자에 있어서의 Tobramycin Pharmacokinetics
Pharmacokinetics of Tobramycin in Patients with Hematologic Malignancy
- Yeom, Mikyong (Department of Nuclear Medicine, Seoul National University) ;
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Shin, Wan-Gyoon
(Department of Pharmacy, Seoul National University Hospital) ;
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Lee, Min-Hwa
(Department of Pharmacy, Seoul National University Hospital)
- 발행 : 1991.05.01
초록
Tobramycin is one of the most frequently selected agents for pharmacokinetic drug monitoring because of its narrow therapeutic index and essential role for the management of serious infections, especially gram-negative infections. Its pharmacokinetic parameters are dependent on race, sex, age, ideal body weight. disease states, and etc. Therefore, to schedule the dosing of tobramycin, the individual pharmacokinetic parameters such as half-life and volume of distribution are needed. However, these pharmacokinetic parameters have never been reported in Koreans. The purposes of this study were to evaluate the volume of distribution of tobramycin in cancer patients who had normal renal function, to compare the mean values of Vd reported in the literature, and to compare the measured half-life with the expected half-life based on ABW, LBW, and IBW, respectively. Venous blood samples were collected just before and thirty minutes after dosing during steady state. Serum tobramycin concentrations were determined by
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