Journal of Pharmaceutical Investigation
- Volume 21 Issue 3
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- Pages.125-132
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- 1991
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Study on the Orientation of Particles in Tablets
정제내부의 입자배열에 관한 연구
- Sohn, Young-Taek (College of Pharmacy, Kangweon National University)
- 손영택 (강원대학교 약학대학)
- Published : 1991.09.20
Abstract
Using X-ray crystallography powder diffraction, the quantitative representation method of preferred orientation of particles ill tablets was developed. Selected faces of a tablet. the upper surface and faces cut parallel and normal to the upper surface, were presented to an X-ray beam and X-ray diffraction patterns for these faces were measured. The effects of particle size. tableting pressure, and particle form on the preferred orientation were also investigated. It was also recognized that the degree of anisotropy in terms of capping tendency was influenced by the preferred orientation of particles in tablets.
Keywords
- preferred orientation;
- tablet;
- acetaminophen;
- X-ray crystallography;
- capping tendency;
- particle shape;
- particle size;
- tableting pressure;
- SEM