Journal of Pharmaceutical Investigation
- 제21권2호
- /
- Pages.85-90
- /
- 1991
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
플루비푸로펜의 1,2-에탄디올에스테르와 1,4-부탄디올에스테르의 생물 약제학적 연구
Biopharmaceutical Studies of 1,2-Ethanediolester and 1,4- Butanediolester of Flurbiprofen
- Rho, Jae-Il (Kyung Dong Pharm. Co.,Ltd.) ;
- Lee, Wan-Ha (College of Pharmacy, Sung Kyun Kwan University)
- 발행 : 1991.06.20
초록
Prodrugs of flurbiprofen, 1,2-ethanediolester(FE) and 1,4-butanediolester(FB) were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution. Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.
키워드