Journal of Pharmaceutical Investigation
- 제21권1호
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- Pages.23-32
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- 1991
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
케토코나졸의 고체분산계에 관한 연구
Studies on Solid Dispersion System of Ketoconazole
- Lee, Chi-Ho (College of Pharmacy, Pusan National University) ;
- Kim, Ki-Heun (College of Pharmacy, Pusan National University) ;
- Choi, Woo-Sik (College of Pharmacy, Pusan National University) ;
- Kim, Jung-Ryang (College of Pharmacy, Pusan National University)
- 발행 : 1991.03.20
초록
Dissolution profiles of ketoconazole in solid dispersion system (SDS) were investigated in the second fluid (pH 6.8) for the dissolution test (KPV). PVP K-30 and methyl cellulose were used as carriers in SDS, and chloroform as a solvent. Computer optimization technique was applied to obtain an optimum formula of SDS, and the following results were obtained; 1) Dissolution rate of ketoconazole in SDS was larger than that of pure ketoconazole in the second fluid of pH 6.8. 2) PVP K-30 and methyl cellulosr were good carriers for SDS of ketoconazole. Moerover PVP K-30 was better than methyl cellulose. 3) The optimum formula of ketoconazole SDS obtained from computer optimization technique was chloroform 175 ml, PVP K-30 5g and methyl cellulose 0.2g per 1g of ketoconazole. 4) The experimental value of