대한약리학회지 (The Korean Journal of Pharmacology)
- 제27권2호
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- Pages.183-189
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- 1991
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- 0377-9459(pISSN)
흰쥐의 착상지연과정중 Estradiol에 의한 자궁내 Prostaglandin 생합성에 미치는 cAMP의 영향
cAMP Mediation in Estradiol-induced Uterine Prostaglandin Synthesis During the Delayed Implantation Process in Rats
- Yoon, Mi-Chung (Endocrine Laboratory, College of Medicine, Yonsei University) ;
- Kim, Chang-Mee (Endocrine Laboratory, College of Medicine, Yonsei University) ;
- Choe, Rim-Soon (Department of Biology, College of Science, Yonsei University) ;
- Ryu, Kyung-Za (Department of Pharmacology, College of Medicine, Yonsei University)
- 발행 : 1991.12.30
초록
본 연구에서는 흰쥐의 착상지연을 유도하여 착상기간동안 자궁조직내 prostaglandin (PG) 생합성이 어떠한 인자에 의해서 조절되는가를 관찰하여 다음과 같은 결과를 얻었다. 흰쥐의 착상지연과정동안 estradiol을 처리하면 처리후 4시간만에 자궁조직내의 cAMP의 농도가 급격하게 증가하였다. PGE와
The present study was performed to elucidate the factors which modulate uterine prostaglandin synthesis during the implantation period in rats, by employing delayed implantation model. Administration of estradiol sharply increased uterine cAMP concentration 4 hrs later during the delayed implantation process. Concentrations of uterine PGE and