The Knoevenagel Reaction of Malononitrile with Acetylacetone: New Route of Pyrazole, Pyrazolo[2,3-C]pyridine, Benzene, Pyridazine and Benzo[C]pyridazine Derivatives

The Knoevenagal reaction of malononitrile and acetylacetone gave the acyclic product 3 which was separated in a good yield and identified. The reactivity of 3 towards some chemical reagents is studied. Thus, the reaction of 3 with aromatic aldehydes, hydrazines and cyanomethylene derivatives gave products 6-12. Reaction of 3 with benzenediazonium chloride gave the primidine derivative 14.