Archives of Pharmacal Research
- 제14권4호
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- Pages.359-363
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of 1,4-Dihydropyridine Carboxylic Acids (III)
- Suh, Jung-Jin (Yuhan Research Center) ;
- Hong, You-Hwa (Yuhan Research Center) ;
- Bae, Myn (Yuhan Research Center)
- 발행 : 1991.12.01
초록
2,6-Dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 5-(2'-cyanoethyl) ester 10a reacted with chloromethyl methylsulfide to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methylthiomethyl 5-(2'-cyanoethyl) ester 11a in 88.1% yield. The synthesis of 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicrboxylic acid 3-methylthiomethyl ester 2a was achieved in 83% yield by alkaline hydrolysis of compound 11a in aqueous EtOH.