YAKHAK HOEJI (약학회지)
- Volume 35 Issue 6
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- Pages.497-503
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- 1991
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis and Biological Activities of New 5-Substituted Uracil Derivatives
새로운 5-치환 Uracil 유도체의 합성 및 생물활성
- Yi, Won-Hui (College of Pharmacy, Chungbuk National University) ;
- Park, Jung-Sup (College of Pharmacy, Chungbuk National University) ;
- Won, Jeong-Hee (College of Pharmacy, Chungbuk National University) ;
- Lee, Chong-Ock (Korea Research Institute of Chemical Technology) ;
- Ryu, Eung-K. (Korea Research Institute of Chemical Technology)
- Published : 1991.12.28
Abstract
Six novel 5-substituted-1-[2-(3-methoxy-2-hydroxyphenyl)-1-methoxyethyl]uracils 2a-f were prepared by condensation of 2,4-bis(trimethylsilyloxy)-5-substituted uracils with 2,7-dimethoxy-2,3-dihydrobenzofuran (9) in the presence of Lewis acid. The 2,3-dihydrobenzofuran derivative 9 was obtained by intramolecular acetalization of 2-acetoxy-3-methoxyphenyl acetaldehyde (8) which was synthesized by oxidative cleavage of 1-allyl-2-acetoxy-3-methoxybenzene (7) using osmium tetroxide followed by
Keywords
- 5-Substituted-1-[2-(3-methoxy~2-hydroxyphenyl)-1-methoxyethyl]uracils;
- antiviral activity;
- antitumor activity