The Korean Journal of Physiology
- Volume 25 Issue 2
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- Pages.159-170
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- 1991
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- 0300-4015(pISSN)
Mechanisms of Contraction Induced by Sodium Depletion in the Rabbit Renal Artery
- Kim, Se-Hoon (Department of Physiology, College of Medicine, Chungnam National University) ;
- Chang, Seok-Jong (Department of Physiology, College of Medicine, Chungnam National University)
- Published : 1991.12.01
Abstract
In the rabbit renal artery, mechanisms of contraction by sodium depletion were investigated. The helical strips of isolated renal artery were immersed in the Tris-buffered salt solution. The contractions were recorded isometrically using a strain-gauge transducer. Na-free solution (Na was substituted by Li, choline or sucrose) produced contractions which were dependent on the nature of the Na substitutes. Na-free solution (choline) produced the contraction in ouabain-pretreated artery (Na loaded artery) even in the presence of verapamil. The amplitude of the contraction was dependent on the duration of the pretreatment with ouabain