Clinical and Experimental Reproductive Medicine
- Volume 17 Issue 1
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- Pages.29-44
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- 1990
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
The Efficacy of a Combination Administration of GnRH Agonist(Lupron) and Gonadotropins for Controlled Ovarian Hyperstimulation in IVF Program
체외수정시술을 위한 과배란유도시 GnRH Agonist(Lupron)와 성선자극호르몬 복합 투여의 효용성에 관한 연구
- Moon, Shin-Yong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
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Lee, Jin-Yong
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
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Chang, Yoon-Seok
(Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
- Published : 1990.06.30
Abstract
In 105 patients with the past history of poor response to the previous controlled ovarian hyperstimulation(COH) due to poor follicular growth or premature LH surge, the effectiveness of pituitary suppression with gonadotropin-releasing hormone agonist(GnRH agonist) in IVF/GIFT program was evaluated in 112 cycles of COH using a combination regimen of Leuprolide acetate (Lupron TAP Pharmaceuticals, USA) and FSH/hMG or pure FSH from May to December, 1989 at SNUH. Starting on day 21 of the menstrual cycle(MCD #21, Day 1), Lupron (1.0mg/day, subcutaneous) was administered once a day till next MCD #3(suppression phase). After the confirmation of pituitary suppression, ovarian follicular growth was stimulated with FSH/hMG or pure FSH from MCD #3(Day + 1), and Lupron was continued with hMG or FSH until hCG administration (D 0) (stimulation phase). After suppression phase, serum E2 level decreased from 183.7
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