Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Serum CA 125 Levels in Patients with Endometriosis

자궁내막증 환자에서 혈청 CA 125치 동태에 관한 연구

  • Lee, Jin-Yong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
  • Yoon, Byung-Koo (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
  • Choi, Young-Min (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
  • Sin, Chang-Jae (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
  • Chang, Yoon-Seck (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
  • 이진용 (서울대학교 의과대학 산부인과학교실) ;
  • 윤병구 (서울대학교 의과대학 산부인과학교실) ;
  • 최영민 (서울대학교 의과대학 산부인과학교실) ;
  • 신창재 (서울대학교 의과대학 산부인과학교실) ;
  • 장윤석 (서울대학교 의과대학 산부인과학교실)
  • Published : 1990.11.30
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Abstract

Serum CA 125 was measured with immunoradiometric assay in fourty-one patients of endometriosis Serum CA 125 levels (Mean ${\pm}$ SEM, U/ml)in patients with endometriosis were 13.8${\pm}$3.3 in stage I , 17.3${\pm}$3.0 in stage II, 23.4${\pm}$4.9 in stage III, and 64.5${\pm}$13.2 in stage IV, which showed increment according to the stage of endometriosis. Serum levels in stage IV only were significantly elvated than those in control (15.3${\pm}$2.2), and those in advanced stage(III and IV ; 47.1${\pm}$9.5)were significantly higher than those in earlier stages (15.9${\pm}$2.2)and control. The assay revealed a sensitivity of 31.7% and the frequency of elevated levels (> 30.3 U/ml)in stage I, II, III and IV was 9. 1%, 18.8%,33.3%, and 87.5% respectively. Sensitivity in advanced stage was higher than that in earlier stage (64.3% vs. 14.8%). There data suggest that serum CA 125 assay might be a useful diagnostic tool in the advanced stage of endometriosis.

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