일부 농촌주민 혈중 Paraoxonase 활성도의 분포 및 관련인자에 관한 조사연구

A Study on the Distributions of Paraoxonase Activity and the Factors affecting Paraoxonase Activity of a Rural Population

  • 송재철 (한양대학교 의과대학 예방의학교실) ;
  • 박항배 (한양대학교 의과대학 예방의학교실)
  • Song, Jae-Cheol (Department of Preventive Medicine, College of Medicine, Hanyang University) ;
  • Park, Hung-Bae (Department of Preventive Medicine, College of Medicine, Hanyang University)
  • 발행 : 1990.06.01

초록

The paraoxonase (E. C. 3.1.1.2) is a major enzyme to detoxicate the organophosphorus and carbamate which are the most widely used as the agricultural spraying insecticides. To investgate the distributions of plasma paraoxonase activity and the factors affecting the enzyme activity, the plasmas of 945 Korean rural population were analysed with the modified Krisch's direct sphectrphotometry method. Three indices of the enzyme activity - basal activity, stimulated activity (by NaCl), % stimulation - were obtained from the analysis. Three indicies suggested unimodal distributions, so we couldn't identify the low activity group risk group to organophosphorus & carbamate insecticides poisoning. There is no significant relation between 3 actvity indicies and sex, age, or history of insecticide use (p>0.05). The basal activity and the stimulated activity have significant relationship and high coefficient of determination with the activities of their parents ($r^2$=0.30, 0.24 ; p<0.05), but the % stimulation does not ($r^2$=0.02 ; p<0.05). These results suggest that the activity of paraoxonase is determined mainly by the genetic factor.

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